They knew in advance it was coming and on the day the paper was published they ignored it entirely. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. Steven Todd Kirsch is an American entrepreneur. Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . Last Checked: 03/03/2023. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. So it was both obvious and convincing the difference between the groups to the workers and the track management. Get your prescription in advance of getting COVID. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. (Clayton Fox, Marty Makary, and Jeffrey Klausner). Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. As noted before, the repository has a link to the 1 hour serotonin lecture. The paramedics will think you are on drugs. There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. Why not fluvoxamine? Mouse Systems is not a household word, he told the journalist. So far, doctors have failed to share his sense of urgency. Still, in the moment, his question threw me, and I stuttered. He was recently featured on 60 Minutes, . I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund [email protected] 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund [email protected] 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? Now they turn to Rust. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. It's hard to ignore this lecture in explaining why the drug is so effective. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. The medical community doesnt care about saving lives. It was tested in. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. Lack of action. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. This looks ominous, but it harmless. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. You will be wired for 24 hours if you dont heed my advice. Medicine today isnt about saving your life. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. I took it myself at that dosage and noticed zero side effects. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . The differences are obvious to untrained eyes. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. Consider masks by contrast. . Physicians who use the drug for COVID now swear by it. Every year, we pick the 10 technologies that matter the most right now. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. I think so. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. Saving the world has been a theme of Kirschs life for years. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. But a panel of key opinion leaders from the NIH, CDC . But the potential upsides. . Both of them encouraged anyone reading this article to get vaccinated. The infectious disease scientists lied to me. There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. Summary of key evidence. just like ivermectin). In severe cases, it takes longer. Avoid caffeine, benadryl, tylenol, and alcohol. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. My favorite dosage is 50mg twice a day for 14 days. I couldnt tell I was on the drug. That covers almost 150,000 of them, which happened before vaccinations began. No long haul symptoms if you start the drug ASAP after first symptoms. Kirsch said that his attempts to promote fluvoxamine are being curtailed. One of the drugs, Fluvoxamine, showed a 30 . of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. If you continue to get this message, The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. The. I have all of these on hand and I load up on vitamin D3 every day. 1:49 It used to be that a Phase 3 study would do it. Is that really true? Then he hosted a superspreader event. If you start 5 days after symptoms, all bets are off. The results would, eventually, set Kirsch on a collision course with the scientific establishment. . Here are the key things you should know about fluvoxamine for COVID: It works. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. This advice is now outdated. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. His latest startup, M10, is a spin-off of a spin-off that sells a blockchain for banks. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. Physicians who use the drug for COVID now swear by it. But not 150K. Medium revoked my account for life. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. How covid-19 conspiracy videos keep getting millions of views. Medicine today isnt about saving your life. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). Always be self aware when using fluvoxamine. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). It does not matter how many lives will be saved. . Have the drug on hand. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . The NIH wrote a bullshit rejection because the FDA told them not to approve it. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 7.76K 31 'This Has Cost Millions Of Lives': Steve Kirsch On Suppression Of Repurposed Drugs And A Spike In Deaths 5 Months After Vaccine Rollout By Jan Jekielek American Thought Leaders / The Epoch Times November 24, 2022 Show more If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. I fixed the link to the fluvoxamine article. Try refreshing this page and updating them one Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Don't underestimate the virus. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Timing is everything with respect to outcomes. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. I think we did rigorous reviews of proposals for research.. Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). Early treatment with existing drugs is the fastest, most effective, and lowest. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. This site requires JavaScript to run correctly. Fluvoxamine is also an Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). Some are views most scientists think are wrong. . We could have saved a lot of lives. There were no studies reported out so far where fluvoxamine made things worse or neutral. Government agencies are ignoring the science. 1 hr ago. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. saying that the per-protocol analysis was arbitrary and other excuses. If you start 5 days after symptoms, all bets are off. How can we get fluvoxamine? While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. Fluvoxamine has a 40 year safety track record. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. It could do nothing. We could have saved a lot of lives. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. MisinformationKills. 36m "We found Fauci was the most highly compensated federal employee. In-patient use. Although the average effect size is 100% with a p-value of <.0001, The Fisher exact test on the combined data suggests that there is a 95% chance that the effect size is at least a 75% reduction in hospitalization rate. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. But Kirsch is also motivated by an unsatisfied competitive streak. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. I've collected fluvoxamine evidence here for convenient access. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. This is what the Seftel trial at Golden Gate fields used. All the supporting observational studies were positive as well. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. He started a covid-19 vaccine company. Kirsch did a lot of things right when he set up CETF. Be warned!. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. One Silicon Valley entrepreneur thought he could beat the odds. It was completed in August. Who knows, Morris replied. . Always be self aware when using fluvoxamine. I believe they made the right decision and we should be rushing to follow their advice. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. Those days are gone. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. . Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. What happens when your prescription drug becomes the center of covid misinformation. Thanks for working tirelessly to help others. And that is what has allowed Kirsch, and people like him, to become so influential. 21. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Twenty-four years ago, . I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. Hes now outlived his initial prognosis by several years. This drug can save your life but you have to ask for it! So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). This is the gold standard of evidence based medicine. He has a BS/MS in Electrical Engineering and Computer Science from MIT. So you can address your OCD and if you get COVID, youll can up the dose. The web price charge of skirsch.io . There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients.
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